NGS sequences millions of fragments in a massively parallel fashion as compared to sequencing a single DNA fragment by Sanger methods. The use of NGS-based tests in both research and clinical practice allows identification of more genetic variants, including rare variants of unknown significance. NGS-based tests also reduce the time needed for sequencing the genome of a large population.
Medical research has embraced the technology and the cancer field is at the forefront of these efforts given the genetic aspects of the disease. NGS is now maturing to the point where it is being considered by many laboratories for routine diagnostic use. The sensitivity, speed and reduced cost per sample make it a highly attractive platform compared to other sequencing modalities.